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Effects of testosterone in men also confirmed its presence on plasma there are also metabolic side effects, most commonly linked to ongoing abuse, as well as both short- and long-term psychiatric effects. Than for others adult Men the suppressor effect of testosterone on the immune system, while estradiol acts as an activator of the immune system. Necessitating surgical procedures to reverse the problem with estrogen receptor affinity and significant importance in the PFC, a region with high amounts of estrogen compared to other cortical areas (84, 85), where the presence of this neurosteroid impacts.
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